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- Title
Decreased glycolyticmetabolismin non-compaction cardiomyopathy by <sup>18</sup>F-fluoro-2-deoxyglucose positron emission tomography: new insights into pathophysiological mechanisms and clinical implications.
- Authors
Tavares de Melo, Marcelo Dantas; Pinto Giorgi, Maria Clementina; Nascimento Assuncao Jr, Antonildes; Nery Dantas Jr, Roberto; de Arimateia Araujo Filho, Jose; Parga Filho, Jose Rodrigues; de Souza Bierrenbach, Ana Luiza; Rocon de Lima, Camila; Soares Jr, José; Claudio Meneguetti, José; Mady, Charles; Abrahao Hajjar, Ludhmila; Kalil Filho, Roberto; Alcides Bocchi, Edimar; Cury Salemi, Vera Maria
- Abstract
Aims The pathophysiological mechanisms of left ventricular non-compaction cardiomyopathy (LVNC) remain controversial. This study performed combined 18 F-fluoro-2-deoxyglucose dynamic positron emission tomography (FDG-PET) and 99mTc-sestamibi single-photon emission computed tomography (SPECT) studies to evaluate myocardial glucose metabolism and perfusion in patients with LVNC and their clinical implications. Methods and results Thirty patients (41 ± 12 years, 53% male) with LVNC, diagnosed by cardiovascular magnetic resonance (CMR) criteria, and eight age-matched healthy controls (42 ± 12 years, 50% male) were prospectively recruited to undergo FDG-PET with measurement of the myocardial glucose uptake rate (MGU) and SPECT to investigate perfusion-metabolism patterns. Patients with LVNC had lower global MGU compared with that in controls (36.9 ± 8.8 vs. 44.6 ± 5.4 lmol/min/100 g, respectively, P = 0.02). Of 17 LV segments, MGU levels were significantly reduced in 8, and also a reduction was observed when compacted segments from LVNC were compared with the segments from control subjects (P < 0.001). Perfusion defects were also found in 15 (50%) patients (45 LV segments: 64.4% match, and 35.6% mismatch perfusion-metabolism pattern). Univariate and multivariate analyses showed that beta-blocker therapy was associated with increased MGU (beta coefficient = 10.1, P = 0.008). Moreover, a gradual increase occurred in MGU across the beta-blocker dose groups (P for trend = 0.01). Conclusion The reduction of MGU documented by FDG-PET in LVNC supports the hypothesis that a cellular metabolic pathway may play a role in the pathophysiology of LVNC. The beneficial effect of beta-blocker mediating myocardial metabolism in the clinical course of LVNC requires further investigation.
- Subjects
ADRENERGIC beta blockers; HEART ventricle diseases; BLOOD sugar; DEOXY sugars; GLYCOLYSIS; LEFT heart ventricle; LONGITUDINAL method; MULTIVARIATE analysis; CARDIOMYOPATHIES; PERFUSION; RADIOPHARMACEUTICALS; STATISTICS; TECHNETIUM; POSITRON emission tomography; SINGLE-photon emission computed tomography
- Publication
European Heart Journal - Cardiovascular Imaging, 2017, Vol 18, Issue 8, p915
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jex036