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- Title
Urea‐catalyzed N‐Glycosylation of Amides/Azacycles with Glycosyl Halides.
- Authors
Wei, Meng‐Man; Ma, Yu‐Feng; Zhang, Gao‐Lan; Li, Qin; Xiong, De‐Cai; Ye, Xin‐Shan
- Abstract
The efficient synthesis of N‐glycosides via direct N‐glycosylation of amides/azacycles has been reported. The glycosylation of amides/azacycles with glycosyl halides in the presence of a catalytic amount of urea proceeded smoothly to provide the corresponding N‐glycosylated amides or nucleosides in good to excellent yields with 1,2‐trans‐stereoselectivity. Moreover, by the addition of terpyridine, the 1,2‐cis‐stereoselectivity was achieved.
- Subjects
HALIDES; NUCLEOSIDES; UREA; GLYCOSYLATION; AMIDES; STEREOSELECTIVE reactions; UREA derivatives
- Publication
Chemistry - An Asian Journal, 2023, Vol 18, Issue 23, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202300791