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- Title
Sıçanlarda Bisfenol A'nın Neden Olduğu Pankreatik Değişimler Üzerine Koenzim Q10'un Etkileri.
- Authors
YILDIZ, Mustafa; GÜLEŞ, Özay; SANDIKÇI, Mustafa; KUM, Şadiye
- Abstract
Background: In the study, it was aimed to determine the changes in the pancreas of rats exposed to bisphenol A (BPA) and to reveal the effects of coenzyme Q10 (CoQ10) on these changes. Materials and Methods: The rats were randomly divided into five groups as follows: control, sham, CoQ10, BPA and CoQ10+BPA. The applications of CoQ10 and BPA continued for fourteen days. Crossmon's triple staining method was applied to the pancreas sections for histopathological and histomorphological examinations. Also, estrogen receptor α (ERα) immunoreactivity on the pancreas tissue was examined immunohistochemically. Results: It was determined that histopathological changes in the endocrine part of the pancreas and ERα immunoreactivity on the pancreatic beta cells significantly increased in BPA group compared to control group. But a significant difference wasn't found between the groups in terms of histomorphological findings. On the other hand, a significant effect of CoQ10 wasn't observed on the parameters analyzed in the study. Conclusion: BPA might cause structural and functional disorders in the pancreas. Also, it might change ERα immunoreactivity, too. However, further studies are required to reveal the possible protective effects of CoQ10 in the pancreas of rats exposed to BPA.
- Subjects
ANIMAL experimentation; RATS; UBIQUINONES
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2020, Vol 17, Issue 3, p335
- ISSN
1304-9623
- Publication type
Article
- DOI
10.35440/hutfd.688689