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- Title
Age Acts as an Adverse Independent Variable for Survival in Acute Lymphoblastic Leukemia: Data From a Cohort in Northeast Mexico.
- Authors
Jaime-Pérez, José Carlos; Fernández, Lucía Teresa; Jiménez-Castillo, Raúl Alberto; Gómez-De León, Andrés; Cantú-Rodríguez, Olga Graciela; Gutiérrez-Aguirre, César Homero; Gómez-Almaguer, David
- Abstract
<bold>Background: </bold>Survival for acute lymphoblastic leukemia (ALL) decreases with age. Patients across all age groups from a homogeneous ethnic and socioeconomic background were studied to document age effect.<bold>Material and Methods: </bold>Patients diagnosed from 2005 to 2015 at a university hospital in Northeast Mexico were divided into 4 age groups: infants (< 1), children (≥ 1 to < 16), adolescents (≥ 16 to ≤ 20), and adults (> 20 years). Correlation between age at diagnosis and relapse-free (RFS) and overall survival (OS) was investigated.<bold>Results: </bold>A total of 377 patients were included. Five-year RFS and OS for children were 55.6% and 66.9%; for adolescents, 36.0% and 48.3%; for adults, 19.5% and 24.1%, respectively. Differences in RFS and OS between age groups were significant (P < .001, P < .001). In the Cox regression model, all age groups reached statistical significance in univariate analysis of mortality.<bold>Conclusion: </bold>Age plays a decisive role in clinical evolution of ALL and strongly influences outcome. Age older than 20 represents a progressive high-risk factor for death.
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2017, Vol 17, Issue 9, p590
- ISSN
2152-2650
- Publication type
journal article
- DOI
10.1016/j.clml.2017.06.016