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- Title
ANAL FISSURE; COMPARISON OF EFFECTIVENESS OF 2% DILTIAZEM OINTMENT TO 0.2% GLYCERYL TRINITRATE OINTMENT IN TREATMENT.
- Authors
Tooba Bukhari, Syeda; Atiq-ur-Rehman, Sheikh; Shoaib Abdullah, Muhammad; Talha Bukhari, Syed; Iqbal, Javid
- Abstract
Objectives: To compare the effectiveness of 2% Diltiazem ointment with 0.2% Glyceryl trinitrate ointment. Place & period: The study was conducted in surgical units, Bahawal Vicotria Hospital, Bahawalpur, Pakistan from 01-01-2016 to 31-12-2016. Material & Method: In this prospective comparative study, 160 patients with anal fissure were equally &randomly divided in two group A (received 2%diltiazem ointment) & group B (received 0.2% Glyceryl trinitrate ointment). The ointment had to be applied to anal verge twice daily for 6-8 weeks. Assessment was done at 2nd, 4th & 6th weekends for fissure healing, pain relief & side effects. Results: Complete fissure healing was observed in 80%of patients in group A & 70% in group B (P<0.15). Pain response was good & was fairly similar in both the groups. Headache occurred in 5% in group A & 20% in group B (P<0.002). Mean time taken for healing of fissure in group A was 5.5±0.28 weeks & in group B was 5.8±0.32 weeks (P< 0.237). Recurrence rate was 7.5% in group A & 17.5% in group B. Conclusion: Topical Diltiazem is preferred to topical Glyceryl trinitrate in the treatment of acute & chronic fissure, because it is associated with a few side effects.
- Subjects
NITROGLYCERIN; DILTIAZEM; OINTMENTS; THERAPEUTICS
- Publication
Professional Medical Journal, 2017, Vol 24, Issue 9, p1354
- ISSN
1024-8919
- Publication type
Article
- DOI
10.17957/TPMJ/17.3918