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- Title
RESISTANCE TO BREAST CANCER TREATMENT INDUCED BY TRANSPORT MECHANISMS.
- Authors
Daniela, Zob; Iuliana, Gruia; Rodica, Anghel
- Abstract
Breast cancer represents the most common form of cancer women develop. Although prognosis has significantly improved over the last years, due to increasing trends in early diagnosis and advanced treatment, the medical community still faces a series of severe problems. One of them is resistance to certain chemotherapy agents that constitutes the main cause of death in more than 90% of patients. Despite intense and thorough studies on resistance mechanisms, their relevance for the clinical practice continues to be unclear. The present paper aims to identify a possible resistance mechanism pattern to chemotherapy applied in breast cancers, which includes the attachment of cytostatics to albumin thiols, as a consequence of oxidized protein degradation. Given their chemical structure, these thiols may be responsible for the impossibility of cytostatics to bind to transport albumins, thus inducing therapeutic failures and implicitly resistance. The content of this article focuses on the measurement of albumin thiol levels in patients diagnosed with breast cancer that developed resistance after the first series of antitumor treatment. We also assessed the level of copper-carrying proteins, namely ceruloplasmin involved in oxidation-reduction reactions as well as the overall level of non-enzymatic endogenous antioxidants. The results reveal the occurrence of a significantly damaging oxidative stress that destroys the structure of transport proteins and, indirectly, can create resistance mechanisms.
- Subjects
BREAST cancer treatment; CANCER chemotherapy; ALBUMINS; CERULOPLASMIN; OXIDATIVE stress; ANTIOXIDANTS; THERAPEUTICS
- Publication
Therapeutics, Pharmacology & Clinical Toxicology, 2014, Vol 18, Issue 1, p12
- ISSN
1583-0012
- Publication type
Article