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- Title
Glutathionyl Hemoglobin Is Elevated in Iron Deficiency Anemia.
- Authors
Shet, A.S.; Pinto, S.M.; Mitra, G.; Mandal, A.K.
- Abstract
There are few good biomarkers of iron deficiency anemia (IDA). Since IDA patients have evidence for increased oxidative stress, we used mass spectrometry (MS) [i.e. matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization] to identify novel biomarkers. Using MALDI-MS, the following oxidative modifications of hemoglobin with the following mass-to-charge ratios were identified: 1,087.5 (α32-40), 1,545.7 (α17-31), 1,290.0 (β31-40) and 2,076.1 (β41-59). On electrospray ionization MS, the IDA patients had significantly elevated glutathionyl hemoglobin (GSHb) compared with the controls (16.9 ± 9.6 vs. 7.7 ± 3.7%; p = 0.002). GSHb levels correlated inversely with serum ferritin (Spearman rho -0.485; p = 0.003) and positively with serum transferrin receptor (0.460; p = 0.002). GSHb also demonstrated inverse correlations with hemoglobin (-0.512; p = 0.001), mean cell volume (-0.419; p = 0.026), serum iron (-0.446; p = 0.008) and transferrin saturation (-0.460; p = 0.008). For the first time, we show that GSHb is elevated in patients with IDA and has potential as a biomarker of this form of anemia. Copyright © 2011 S. Karger AG, Basel
- Subjects
HEMOGLOBINS; IRON deficiency anemia; BIOMARKERS; BLOOD proteins; FERRITIN; TRANSFERRIN
- Publication
Acta Haematologica, 2011, Vol 127, Issue 1, p26
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000330945