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- Title
An experimental model of mitochondrial myopathy: Germanium-induced myopathy and coenzyme Q<sub>10</sub> administration.
- Authors
Wu, Chien-Ming; Matsuoka, Taro; Takemitsu, Masakazu; Goto, Yu-Ichi; Nonaka, Ikuya
- Abstract
In skeletal muscles from rats treated with germanium for 23 weeks, there were numerous ragged-red fibers and cytochrome- c oxidase (COX)-deficient fibers. Biochemically, germanium reduced the enzyme activities in the mitochondrial respiratory chain. Rotenone-sensitive NADH-cytochrome- c reductase as well as COX activities were markedly reduced, while succinate-cytochrome- c reductase was less severely, but significantly, affected. The histopathological findings in these muslces were similar to those seen in patients with mitochondrial encephalomyopathy, suggesting that germanium-induced myopathy may be a useful experimental model. Coenzyme Q10 administration appeared to be ineffective in preventing this experimental myopathy. © 1992 John Wiley & Sons, Inc.
- Publication
Muscle & Nerve, 1992, Vol 15, Issue 11, p1258
- ISSN
0148-639X
- Publication type
Article
- DOI
10.1002/mus.880151107