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- Title
Deaths related to Chagas disease and HIV/AIDS coinfection in Brazil: a nationwide population-based analysis.
- Authors
Martins-Melo, Francisco Rogerlândio; Castro, Marcia C; Werneck, Guilherme Loureiro; Heukelbach, Jorg
- Abstract
Background Trypanosoma cruzi /HIV coinfection has been described as a relevant clinical event and an emerging public health problem. Here, we describe the epidemiological patterns of deaths related to Chagas disease and HIV/AIDS coinfection in Brazil from 2000 to 2019. Methods We performed a nationwide population-based study using mortality data obtained from the Brazilian Mortality Information System. We included all deaths recorded in Brazil from 2000 to 2019 in which Chagas disease and HIV/AIDS were mentioned on the same death certificate, either as underlying or as associated causes of death. Results Chagas disease and HIV/AIDS were mentioned on 196/22 663 092 death certificates. HIV/AIDS was the underlying cause in 58.2% (114/196) of deaths and Chagas disease in 33.2% (65/196). The average annual mortality rate was 0.05 deaths/1 000 000 inhabitants (95% CI 0.03 to 0.09). The highest death rates were found among males, those aged 60–69 y, Afro-Brazilians, those with 1–3 y of schooling/study and residents in Chagas disease-endemic regions/states. Respiratory, infectious/parasitic and cardiovascular diseases/disorders were the associated causes of death most commonly mentioned. Conclusions Mortality due to Chagas disease and HIV/AIDS coinfection may be largely underestimated in Brazil. Our data further reinforce the importance of screening for T. cruzi infection in HIV-infected patients from Chagas disease-endemic areas. Appropriate clinical management should be ensured for Chagas disease and HIV coinfected patients.
- Subjects
BRAZIL; CHAGAS' disease; AIDS; MIXED infections; PARASITIC diseases; HIV; HIV seroconversion; AIDS-related opportunistic infections
- Publication
Transactions of the Royal Society of Tropical Medicine & Hygiene, 2022, Vol 116, Issue 6, p579
- ISSN
0035-9203
- Publication type
Article
- DOI
10.1093/trstmh/trab183