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- Title
Drug-induced fatty liver disease: An overview of pathogenesis and management.
- Authors
Satapathy, Sanjaya K.; Kuwajima, Vanessa; Nadelson, Jeffrey; Atiq, Omair; Sanyal, Arun J.
- Abstract
Over the past decades, many drugs have been identified, that can potentially induce steatohepatitis in the predisposed individual. Classically this has been incriminated to amiodarone, perhexiline, and 4,4'-diethylaminoethoxyhexestrol (DH), all of which have been found to independently induce the histologic picture of non-alcoholic steatohepatitis (NASH). Pathogenetic mechanisms of hepatotoxicity although still evolving, demonstrate that mitochondrial dysfunction, deranged ATP production and fatty acid catabolism likely play an important role. Drugs like steroid hormones can exacerbate the pathogenetic mechanisms that lead to NASH, and other drugs like tamoxifen, cisplatin and irenotecan have been shown to precipitate latent fatty liver as well. Further research aiming to elucidate the pathogenesis of drug-induced steatosis and steatohepatitis is needed in order to better design therapeutic targets.
- Subjects
FATTY liver; DRUG side effects; AMIODARONE; PERHEXILINE; HEPATOTOXICOLOGY; FATTY degeneration; THERAPEUTICS; DISEASE risk factors
- Publication
Annals of Hepatology: Official Journal of the Mexican Association of Hepatology, 2015, Vol 14, Issue 6, p789
- ISSN
1665-2681
- Publication type
Article
- DOI
10.5604/16652681.1171749