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- Title
EGb 761 SUPPLEMENTATION INCREASES MANGANESE CONTENT IN MOUSE BRAIN IN AN ANIMAL MODEL OF PARKINSON'S DISEASE.
- Authors
Rojas, Carolina; Montes, Sergio; Rojas, Patricia
- Abstract
EGb761 is a patented and well-defined mixture of active compounds extracted from Ginkgo biloba leaves with neuroprotective effects, in part via its antioxidant or free radical scavenger action. It has neuroprotective effects in an animal model of Parkinson's disease induced by 1-methyl-4-phenylpyridinium (MPP+). Because manganese plays an important role in brain function and its reduction has been reported in Parkinson's disease, we investigated whether EGb761's protective effect in MPP+ neurotoxicity is related to the regulation of manganese in the brain. C-57BL/6J mice were pretreated with EGb761 (10 mg/kg) daily for 17 days followed by administration of MPP+ (0.72 mg/kg); the mice were sacrificed 24 h later. The manganese content of striatum, hypothalamus, midbrain, hippocampus, prefrontal cortex, and cerebellum was analyzed by graphite furnace atomic absorption spectrophotometry. Manganese content was significantly reduced in midbrain (12%), hypothalamus (20%) and cerebellum (19%) after MPP+ administration. EGb761 pretreatment to the MPP+ group prevented reduction in the manganese content of midbrain. No significant changes were found in the manganese content of the striatum, hypothalamus, cerebellum, hippocampus and prefrontal cortex in the "EGb761 + MPP+" group compared to the "saline + MPP+" group. The neuroprotective effect of EGb761 against MPP+ neurotoxicity may be due, in part, to the regulation of manganese homeostasis in the brain.
- Subjects
GINKGO; MANGANESE content of plants; LABORATORY mice; PARKINSON'S disease; FREE radical scavengers; ANTIOXIDANTS; BRAIN degeneration; THERAPEUTICS
- Publication
Current Topics in Nutraceutical Research, 2014, Vol 12, Issue 1/2, p57
- ISSN
1540-7535
- Publication type
Article