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- Title
Patterns of expression of a tumor associated antigen, defined by the monoclonal antibody HMFG2, in human epithelial ovarian carcinoma. Comparison with expression of the HMFG1, AUA1 and F36/22 antigens.
- Authors
Ward, Bruce G.; Lowe, David G.; Shepherd, John H.; Ward, B G; Lowe, D G; Shepherd, J H
- Abstract
Binding to the antigen defined by the monoclonal antibody HMFG2 was demonstrated in more than 94% of human epithelial ovarian carcinomas by the indirect immunoperoxidase technique. The extent of the expression of this antigen related to tumor differentiation; well-differentiated tumors expressed more antigen than poorly differentiated tumors. Marked variation of tumor grade and antigen expression was demonstrated in individual tumors and this may be a limiting factor in the use of radioisotope linked HMFG2 for tumor therapy. A similar prevalence was found in the expression of the antigens defined by the monoclonal antibodies HMFG1 and F36/22; whereas the AUA1 antigen was demonstrated in 68% of cases. The patterns of expression of the HMFG1, HMFG2, and F36/22 antigens suggest that they may be related antigens.
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 4, p787
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870815)60:4<787::AID-CNCR2820600414>3.0.CO;2-M