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- Title
Malignant fibrous histiocytoma of bone. The experience at the Rizzoli Institute: report of 90 cases.
- Authors
Capanna, Rodolfo; Bertoni, Franco; Bacchini, Patrizia; Bacci, Gaetano; Guerra, Aristide; Campanacci, Mario; Capanna, R; Bertoni, F; Bacchini, P; Bacci, G; Guerra, A; Campanacci, M
- Abstract
Ninety cases of malignant fibrous histiocytoma (MFH) of bone are reported. An analysis is presented with regard to sex, age, site, symptoms, radiography, macroscopic, and microscopic features. The staging was assessed according to the following classification: I B: 3 cases; II A: 11 cases; II B: 66 cases; III: 10 cases. Among nonmetastatic patients, 68 had surgical treatment (adequate, 46; inadequate, 22); 8 had radiotherapy, and 3 refused any treatment. Among surgically treated patients, 20 had adjuvant chemotherapy, also. Follow-up information was obtained in all cases. Overall survival rates were 34% at 5 years, and 28% at 10 years. Surgery alone did not appear to be successful (5-year survival, 28%). Adjuvant chemotherapy improved the survival rate only in patients who underwent adequate surgery (5-year survival, 57%). The recurrence rate after surgical treatment was high (31%) with significant differences after inadequate (64%), wide (19%), or radical (6.5%) surgical treatment. Adjuvant chemotherapy was ineffective in preventing local recurrence. Radiation therapy effected a clinical cure in three cases; the authors believe that radiation therapy has to be used only in inoperable tumors.
- Publication
Cancer (0008543X), 1984, Vol 54, Issue 1, p177
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19840701)54:1<177::AID-CNCR2820540133>3.0.CO;2-C