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- Title
Leptomeningeal mycosis fungoides.
- Authors
Lundberg, W. B.; Cadman, E. C.; Skeel, R. T.
- Abstract
Central nervous system involvement with mycosis fungoides complicated the clinical course of a patient at a time when his skin was clinically free of disease following systemic chemotherapy. A leptomeningeal syndrome of blurred vision and papilledema, and confusion progressing to coma, was associated with elevated spinal fluid pressure and abnormal spinal fluid cells morphologically similar to those seen in the Sezary syndrome. The symptoms were dramatically reversed by intrathecal methotrexate, brain irradiation, and steroids. Mycosis fungoides recurred in the skin, in the spinal fluid, and in both eyes. Despite continued systemic and intrathecal chemotherapy, the patient died from mycosis fungoides. This is the second patient reported with meningeal mycosis fungoides.
- Publication
Cancer (0008543X), 1976, Vol 38, Issue 5, p2149
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197611)38:5<2149::AID-CNCR2820380545>3.0.CO;2-A