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- Title
Duodenal application of Li+ in a submaximal therapeutic dose inhibits exocrine pancreatic secretion and modulates gastro-duodenal myoelectrical activity in a conscious pig model.
- Authors
Naughton, Violetta; Hedemann, Mette S.; Naughton, Patrick J.; McSorley, Emeir; Laerke, Helle N.
- Abstract
This study tested whether duodenal application of lithium inhibits gastroduodenal motility, and whether it suppresses secretion from the exocrine pancreas. Five suckling pigs, 16-18 days old, were surgically fitted with 3 serosal electrodes on the wall of the gastric antrum and the duodenum for electromyography of smooth muscles, and with a pancreatic duct catheter and a duodenal T-cannula for collection and re-entrant flow of pancreatic juice. After the recovery period, on alternative days, each animal was tested once with an intraduodenal infusion of Li+ (100 mmol·L-1 C3H5LiO3, 10 mL·kg−1·h−1) for 1 h, and once with an intraduodenal infusion of NaCl (154 mM, 10 ml·kg−1·h−1), also for 1 h, with the first treatment, i.e., Li+ or NaCl, randomly assigned. Individual pigs served as their own controls, with data recorded prior to a treatment being used as the baseline. Li+ increased the duration of quiescence ( P < 0.05) and activity phase ( P < 0.05) in the antrum, thus increasing ( P < 0.05) the duration of antral myoelectrical cycles. Li+ shortened ( P < 0.05) phase I, but it did not affect phase II or phase III or the MMC in the duodenum. Li+ inhibited pancreatic juice outflow as well as pancreatic enzyme and bicarbonate output ( P < 0.05 for all pancreatic parameters).
- Subjects
THERAPEUTIC use of lithium; DUODENAL diseases; EXOCRINE secretions; PANCREATIC enzymes; LABORATORY swine; PANCREATIC secretions
- Publication
Canadian Journal of Physiology & Pharmacology, 2013, Vol 91, Issue 9, p764
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2012-0396