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- Title
A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?
- Authors
Dahl, Jesper; Skogen, Bjørn; Kjaer, Mette; Husebekk, Anne; Kjeldsen‐Kragh, Jens; Tiller, Heidi; Kjeldsen-Kragh, Jens
- Abstract
<bold>Background: </bold>Maternal anti-human leukocyte antigen (HLA) Class I is commonly detected alongside anti-human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT.<bold>Methods and Materials: </bold>We reanalyzed samples originally collected as part of a large Norwegian screening study on FNAIT during 1995-2004. This study identified and managed 170 pregnancies where the mother was HPA-1a negative and had detectable anti-HPA-1a during pregnancy. Maternal samples from 166 of these pregnancies were rescreened for anti-HLA Class I, revealing 111 (67%) that were antibody positive. Various regression models were used to assess if and how maternal anti-HLA Class I influenced the neonatal platelet count.<bold>Results and Conclusions: </bold>Unadjusted neonatal platelet counts and the frequency of neonatal thrombocytopenia was not significantly affected by the presence of anti-HLA Class I alongside anti-HPA-1a, but results from regression analyses revealed a possible increased risk when the mother was nulliparous. These results warrant further investigation.
- Subjects
PLATELET count; PREGNANCY; MOTHERS; REGRESSION analysis; THROMBOCYTOPENIA; AUTOANTIBODIES; RETROSPECTIVE studies; FETAL diseases; RESEARCH funding; HISTOCOMPATIBILITY antigens; ANTIGENS
- Publication
Transfusion, 2020, Vol 60, Issue 9, p2121
- ISSN
0041-1132
- Publication type
journal article
- DOI
10.1111/trf.15944