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- Title
Changes in epileptic spike configuration associated with attainment of seizure control.
- Authors
Frost, James D.; Kellaway, Peter; Hrachovy, Richard A.; Glaze, Daniel G.; Mizrahi, Eli M.
- Abstract
This study provides preliminary evidence that computer-derived parameters of interictal spike waveforms can be used to assess seizures hazard in a quantitative manner. Thirteen children with spike foci and simple or complex partial seizures were studied before and during treatment with carbamazepine or phenobarbital; spike parameters were determined from 5- to 30-minute electroencephalographic samples obtained during non-rapid eye movement sleep. Measurements included spike amplitude, duration, and sharpness, and a mathematical combination of these three parameters (the composite spike parameter). Achievement of seizure control was associated with a decrease in spike amplitude, duration, and composite spike parameter, and an increase in normalized sharpness, compared to baseline values. These result suggest that this method may provide a prospective means for estimating drug efficacy that can be applied shortly after attainment of steady-state serum drug levels.
- Publication
Annals of Neurology, 1986, Vol 20, Issue 6, p723
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410200612