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- Title
Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases.
- Authors
Johnson, Richard T.; Burke, Donald S.; Elwell, Michael; Leake, Colin J.; Nisalak, Ananda; Hoke, Charles H.; Lorsomrudee, Wanida
- Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.
- Publication
Annals of Neurology, 1985, Vol 18, Issue 5, p567
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410180510