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- Title
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
- Authors
Childs, Erica J; Scelo, Ghislaine; Brennan, Paul; Amundadottir, Laufey T; Chanock, Stephen J; Hoover, Robert N; Bamlet, William R; Chaffee, Kari G; Oberg, Ann L; Petersen, Gloria M; Bijlsma, Maarten F; Brenner, Hermann; Bueno-de-Mesquita, H Bas; Canzian, Federico; Rizzato, Cosmeri; Capurso, Gabriele; Cavestro, Giulia M; Cleary, Sean P; Mocci, Evelina; Blackford, Amanda
- Abstract
Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10−14), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10−8) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10−8). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10−9), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk.
- Subjects
NORTH America; AUSTRALIA; GENOMES; CENTRAL Europeans; POPULATION
- Publication
Nature Genetics, 2015, Vol 47, Issue 8, p911
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.3341