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- Title
Genome-wide association study of blood pressure and hypertension.
- Authors
Levy, Daniel; Ehret, Georg B.; Rice, Kenneth; Verwoert, Germaine C.; Launer, Lenore J.; Dehghan, Abbas; Glazer, Nicole L.; Morrison, Alanna C.; Johnson, Andrew D.; Aspelund, Thor; Aulchenko, Yurii; Lumley, Thomas; Köttgen, Anna; Vasan, Ramachandran S.; Rivadeneira, Fernando; Eiriksdottir, Gudny; Xiuqing Guo; Arking, Dan E.; Mitchell, Gary F.; Mattace-Raso, Francesco U. S.
- Abstract
Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7. The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10−8) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.
- Subjects
BLOOD pressure; HYPERTENSION; CARDIOVASCULAR diseases risk factors; CARDIAC contraction; DIASTOLE (Cardiac cycle); GENOMICS
- Publication
Nature Genetics, 2009, Vol 41, Issue 6, p677
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.384