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- Title
Diminished Expression of CD59 on Activated CD8[sup +] T Cells Undergoing Apoptosis in Systemic Lupus Erythematosus and Sjögren's Syndrome.
- Authors
Tsunoda; Kawano; Koni; Kasahara; Yachie; Miyawaki; Seki
- Abstract
The present study was undertaken to examine the phenotype of T cells undergoing in vitro apoptosis in patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS). Compared with normal controls, we found diminished expression of CD59 antigen (one of the cell-surface complement-regulatory proteins) on CD8[sup +] T cells, but not on CD4[sup +] T cells, from patients with SLE and SS. Three-colour immunofluorescence analysis revealed that these CD59[sup dim ]CD8[sup +] T cells were activated T cells, expressing both human leucocyte antigen (HLA)-DR and CD45RO antigens. In addition, these CD59[sup dim ]CD8[sup +] T cells were more susceptible to in vitro apoptosis than CD59[sup bright ]CD8[sup +] T cells. In two patients with active lupus, the percentage of CD59[sup dim ]CD8[sup +] T cells was significantly decreased after steroid therapy. These findings suggest that decreased expression of CD59 antigen on in vivo-activated CD8[sup +] T cells may be correlated with disease activity and may be involved in activation-induced apoptosis in patients with SLE and SS.
- Subjects
PHENOTYPES; APOPTOSIS; SYSTEMIC lupus erythematosus; SJOGREN'S syndrome
- Publication
Scandinavian Journal of Immunology, 2000, Vol 51, Issue 3
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2000.00674.x