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- Title
Adjuvant Properties of Montanide CSA 720 with a Recombinant HIV PI 7 gag Protein and Synthetic Pep tide Antigens.
- Authors
Kirkley, J. E.; Goldstein, A. L.; Naylor, P. H.
- Abstract
The adjuvant properties of Montanide CSA 720 were assessed in a comparison with alum, BALB/c mice were immunized with recombinant HIV-1 <em>gag</em> protein p17 administered in either of the two adjuvants. The serum antibody response to p17 with Montanide CSA 720 appeared faster and reached a higher titre than with alum. The serum antibody response to p17 in Montanide CSA 720 was further characterized by a higher titre antibody directed against a 30 amino acid segment from the entire protein. The Montanide CSA 720 adjuvant was sufficiently strong to induce an antibody response against a weak synthetic peptide immunogen after two immunizations, while immunization with the peptide in alum generated no detectable serum antibody. The p17-specific proliferative response of splenocytes from animals immunized with recombinant protein in either adjuvant was similar.
- Subjects
IMMUNOLOGICAL adjuvants; RECOMBINANT proteins; IMMUNOGLOBULINS; IMMUNE response; AMINO acids
- Publication
Scandinavian Journal of Immunology, 1996, Vol 43, Issue 4, p431
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1996.d01-60.x