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- Title
Lyme Neuroborreliosis: Evidence for Persistent Up-Regulation of Borrelia Burgdorferi-Reactive Cells Secreting Interferon-γ.
- Authors
Wang, W.-Z.; Fredrikson, S.; Sun, J.-B.; Link, H.
- Abstract
The T-cell response to the aetiologic pathogen <em>Borrelia (B.) burgdorferi</em> in patients with Lyme neuroborreliosis (LN) and in control patients with other neurological diseases was examined by enumerating <em>B. burgdorferi</em>-reactive T cells secreting interferon-γ (IFN-γ) with an ELIspot assay. LN patients had elevated numbers of <em>B. burgdorferi</em>-reactive IFN-γ secreting cells in blood and approximately 20-fold enriched in the cerebrospinal fluid (CSF). A positive correlation existed in CSF between <em>B. burgdorferi</em>-reactive IFN-γ secreting cells and B cells secreting anti-<em>B. burgdorferi</em> IgG antibodies. The up-regulation of antigen-specific IFN-γ secreting cells persisted in peripheral blood up to at least 9 months and in the CSF for at least 4 months after termination of treatment with antibiotics, when the patients were mostly free from clinical signs and symptoms due to LN. How IFN-γ interplays with other cytokines and influences the pathogenesis of LN remains to be studied.
- Subjects
T cells; LYMPHOCYTES; PATHOGENIC microorganisms; BORRELIA burgdorferi; LYME disease
- Publication
Scandinavian Journal of Immunology, 1995, Vol 42, Issue 6, p694
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1995.tb03713.x