We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys.
- Authors
Valette, H.; Bottlaender, M.; Dollé, F.; Coulon, C.; Ottaviani, M.; Syrota, A.
- Abstract
The aim of this study was to compare the degree of occupancy of central nicotinic acetylcholine receptors (nAChR) in isoflurane anaesthetized baboon brain following inhalation of tobacco smoke (one cigarette containing 0.9 mg nicotine) or i.v. nicotine (0.6 mg i.v.). [[sup 18] F]Fluoro-A-85380 and positron emission tomography (PET) were used to assess the distribution volumes (DV) of the radiotracer in selected brain areas using a one-compartment model. Eighty minutes after nicotine i.v., DV was reduced by 50 and 66% in the thalamus and putamen, respectively. Six hours after nicotine, a reduction in DV (27% in the thalamus) was still observed. Eighty minutes after inhalation of tobacco smoke, DV was decreased by 52 and 65% in the thalamus and putamen, respectively. Previous PET experiments have demonstrated a short-lasting interaction of [[sup 11] C]nicotine with nAChRs. Thus, we hypothesized that a metabolite of nicotine with high affinity and long half-live (several hours) could bind at nAChRs. Eighty minutes after a high dose of nornicotine (0.5 mg i.v.), DV was reduced by 53 and 31% in thalamus and putamen, respectively. No significant effect was observed following 0.15 mg nornicotine. Therefore, nornicotine could contribute to the long-lasting occupancy of central nAChRs after smoking.
- Subjects
NICOTINIC receptors; TOBACCO smoke; NICOTINE
- Publication
Journal of Neurochemistry, 2003, Vol 84, Issue 1, p105
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.2003.01502.x