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- Title
Effect of andrographolide on phosphatases activity and cytotoxicity against Spodoptera litura.
- Authors
Edwin, E.; Vasantha-Srinivasan, P.; Senthil-Nathan, S.; Thanigaivel, A.; Ponsankar, A.; Selin-Rani, S.; Kalaivani, K.; Hunter, W. B.; Duraipandiyan, V.; Al-Dhabi, N. A.
- Abstract
Andrographolide was isolated from ethanol extraction of Andrographis paniculata by column chromatography. Evaluation of larvicidal efficacy, enzymatic changes and cytotoxic activities against Spodoptera litura were conducted across a range of concentrations. The compound showed significant larvicidal activity between 5 - 25 ppm, post ingestion. Morphological deformities observed in larval-pupal stages. Enzymatic profiles were altered by reduction in acid phosphatase, ACP activity by 69.18 %, alkaline phosphatase, ALP activity 75.3 % and 74.9 % reduction in ATPase. Binding affinity to midgut epithelium cells suggests disintegration of cellular organelles observed was directly associated with ingestion of the compound. The results suggest that andrographolide has potential for development as a significant inhibitor of development against the pest Spodoptera litura.
- Subjects
SPODOPTERA littoralis; PHOSPHATASES; CELL-mediated cytotoxicity
- Publication
Invertebrate Survival Journal, 2016, Vol 13, p153
- ISSN
1824-307X
- Publication type
Article