We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Deceleration of fetal growth rate as alternative predictor for childhood outcomes: a birth cohort study.
- Authors
Broere-Brown, Zoe A.; Schalekamp-Timmermans, Sarah; Jaddoe, Vincent W. V.; Steegers, Eric A. P.
- Abstract
<bold>Background: </bold>Small for gestational age (SGA) is frequently used to define fetal growth restriction (FGR). However, FGR describes a slowdown in fetal growth and is not synonymous with SGA, which may introduce misclassification. We investigated the effect of both on delivery and childhood outcomes.<bold>Methods: </bold>From a prospective population-based cohort study we included 7959 live singleton births with data available on second trimester estimated fetal weight (EFW) and birth weight. We used a decrease in growth of > 40 percentiles between second trimester EFW and birthweight to define a deceleration in growth. SGA was defined as birthweight <p5.<bold>Results: </bold>Deceleration of growth occurred in 27,2% in SGA neonates and in 10,3% of neonates with an appropriate for gestational age (AGA) birthweight. Of all fetuses with decelerated growth, 90% was born AGA. SGA neonates were more often delivered by instrumental delivery or cesarean section and admitted to NICU. Both decelerated growth and SGA were associated with accelerated growth at 2 years, a smaller aortic diameter and lower left ventricular mass at 6 years.<bold>Conclusions: </bold>Both decelerated growth and SGA are associated with unfavorable clinical outcomes in childhood. In addition to SGA, neonates with deceleration of growth should be considered a high-risk group.
- Subjects
FETAL development; CHILDREN; GESTATIONAL age; BIRTH weight; COHORT analysis
- Publication
BMC Pregnancy & Childbirth, 2019, Vol 19, Issue 1, pN.PAG
- ISSN
1471-2393
- Publication type
journal article
- DOI
10.1186/s12884-019-2358-8