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- Title
A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.
- Authors
Ohashi, Jun; Naka, Izumi; Doi, Akihiro; Patarapotikul, Jintana; Hananantachai, Hathairad; Tangpukdee, Noppadon; Looareesuwan, Sornchai; Tokunaga, Katsushi
- Abstract
Background: IL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T. Methods: To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malaria and 203 mild malaria patients). Results: In this population, IL1B -31C>T and IL1RA VNTRwere detected, while IL1B 3953C>T (i.e., IL1B 3953T) was not observed in the polymorphism screening for 32 patients. Further analyses for IL1B -31C>T and IL1RA VNTR in 110 cerebral malaria and 206 mild malaria patients showed no significant association of these polymorphisms with cerebral malaria. Conclusion: The present results suggest that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria.
- Subjects
MALARIA; BRAIN diseases; GENETIC polymorphisms; BLOOD plasma; FEVER
- Publication
Malaria Journal, 2005, Vol 4, p1
- ISSN
1475-2875
- Publication type
Article
- DOI
10.1186/1475-2875-4-38