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- Title
Inhibitory Effects of Gymnema (Gymnema sylvestre) Leaves on Tumour Promotion in Two-Stage Mouse Skin Carcinogenesis.
- Authors
Ken Yasukawa; Sakiko Okuda; Yasuhito Nobushi
- Abstract
Ethanol extracts of gymnema (Gymnema sylvestre) leaves exhibited marked antitumour-promoting activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the ethanol extract of the gymnema leaves, three triterpenoids were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 μg/ear) in mice. The tested compounds showed marked anti-inflammatory effects, with a 50% inhibitory dose of 50-555 nmol/ear.
- Subjects
JAPAN; THERAPEUTIC use of plant extracts; SKIN tumors; HYDROCARBON metabolism; ANIMAL experimentation; BIOLOGICAL models; BIOPHYSICS; CONFIDENCE intervals; DOSE-response relationship in biochemistry; EAR; GAS chromatography; HIGH performance liquid chromatography; INFLAMMATION; MASS spectrometry; RESEARCH methodology; MICE; PAPILLOMA; REGRESSION analysis; RESEARCH funding; T-test (Statistics); PLANT extracts; NEOPLASTIC cell transformation; MANN Whitney U Test; PREVENTION
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/328684