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- Title
Impact of Rivastigmine Patch and Capsules on Activities of Daily Living in Alzheimer’s Disease.
- Authors
Grossberg, George; Xiangyi Meng; Olin, Jason T.
- Abstract
Background: Rivastigmine patches provide similar efficacy to rivastigmine capsules with a lower incidence of gastrointestinal side effects in patients with probable Alzheimer’s disease (AD). Methods: Post hoc analysis of a 24-week, prospective, international, randomized, double-blind, placebo- and active-controlled trial. Patients (n = 892) with probable AD received rivastigmine transdermal patches (9.5 mg/24 hours [10 cm2]), rivastigmine capsules (6 mg twice daily), or placebo, and impact on activities of daily living (ADLs) was assessed utilizing 3 subscales: basic, high-level function, and autonomy. Results: At week 24, both rivastigmine groups demonstrated significantly superior performance in Alzheimer’s Disease Cooperative Study—Activities of Daily Living (ADCS-ADL) Total Score versus placebo (rivastigmine patch, P = .013; capsules, P = .039). Overall, both rivastigmine formulations provided benefits in ADL subscales. For basic ADLs, rivastigmine capsules performed significantly better than placebo (P = .012). For high-level function ADLs, rivastigmine patch performed better than placebo (P = .056). For autonomy ADLs, rivastigmine patch performed significantly better than placebo (P = .017). Conclusion: Rivastigmine patches and capsules provide significant effects in both total and subscale ADLs in patients with probable AD.
- Subjects
CHOLINESTERASE inhibitors; ACTIVITIES of daily living; ALZHEIMER'S disease; ANALYSIS of variance; LONGITUDINAL method; PROBABILITY theory; RESEARCH funding; STATISTICS; DATA analysis; RANDOMIZED controlled trials; OLD age; THERAPEUTICS
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2011, Vol 26, Issue 1, p65
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/1533317510391240