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- Title
Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers.
- Authors
Gersel Stokholm, Morten; Garrido, Alicia; Tolosa, Eduardo; Serradell, Mónica; Iranzo, Alex; Østergaard, Karen; Borghammer, Per; Møller, Arne; Parbo, Peter; Stær, Kristian; Brooks, David J.; Martí, Maria José; Pavese, Nicola
- Abstract
Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal 18F-DOPA uptake. Three of them had significantly raised nigral 11C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD.
- Subjects
MICROGLIA; INFLAMMATION; PARKINSON'S disease; DOPAMINE analysis; PARKINSONIAN disorders; FRACTALKINE
- Publication
Journal of Neurology, 2020, Vol 267, Issue 8, p2296
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-020-09830-3