We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Higher frequencies of HLA DQB1*05:01 and anti-glycosphingolipid antibodies in a cluster of severe Guillain-Barré syndrome.
- Authors
Schirmer, L.; Worthington, V.; Solloch, U.; Loleit, V.; Grummel, V.; Lakdawala, N.; Grant, D.; Wassmuth, R.; Schmidt, A.; Gebhardt, F.; Andlauer, T.; Sauter, J.; Berthele, A.; Lunn, M.; Hemmer, Bernhard
- Abstract
Few regional and seasonal Guillain-Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni ( Cj). We examined 40 consecutive patients with GBS from the greater Munich area in Germany with 14 of those admitted within a period of 3 months in fall 2010 defining a cluster of GBS. Sequencing-based HLA typing of the HLA genes DRB1, DQB1, and DPB1 was performed, and ELISA for anti-glycosphingolipid antibodies was carried out. Clinical and paraclinical findings ( Cj seroreactivity, cerebrospinal fluid parameters, and electrophysiology) were obtained and analyzed. GBS cluster patients were characterized by a more severe clinical phenotype with more patients requiring mechanical ventilation and higher frequencies of autoantibodies against sulfatide, GalC and certain ganglioside epitopes (54 %) as compared to sporadic GBS cases (13 %, p = 0.017). Cj seropositivity tended to be higher within GBS cluster patients (69 %) as compared to sporadic cases (46 %, p = 0.155). We noted higher frequencies of HLA class II allele DQB1*05:01 in the cluster cohort (23 %) as compared to sporadic GBS patients (3 %, p = 0.019). Cluster of severe GBS was defined by higher frequencies of autoantibodies against glycosphingolipids. HLA class II allele DQB1*05:01 might contribute to clinical worsening in the cluster patients.
- Subjects
GUILLAIN-Barre syndrome; GLYCOSPHINGOLIPIDS; ANTIBODY formation; CAMPYLOBACTER jejuni; SULFATIDES; GANGLIOSIDES; ENZYME-linked immunosorbent assay
- Publication
Journal of Neurology, 2016, Vol 263, Issue 10, p2105
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-016-8237-6