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- Title
Lipo-Poly(L-histidine) Hybrid Materials with pH-Sensitivity, Intracellular Delivery Efficiency, and Intrinsic Targetability to Cancer Cells.
- Authors
Johnson, Renjith P.; Jeong, Young‐Il; John, Johnson V.; Chung, Chung‐Wook; Choi, Seon Hee; Song, Song Yi; Kang, Dae Hwan; Suh, Hongsuk; Kim, Il
- Abstract
Biocompatible lipo-histidine hybrid materials conjugated with IR820 dye show pH-sensitivity, efficient intracellular delivery of doxorubicin (Dox), and intrinsic targetability to cancer cells. These new materials form highly uniform Dox-loaded nanosized vesicles via a self-assembly process showing good stability under physiological conditions. The Dox-loaded micelles are effective for suppressing MCF-7 tumors, as demonstrated in vitro and in vivo. The combined mechanisms of the EPR effect, active internalization, endosomal-triggered release, and drug escape from endosomes, and a long blood circulation time, clearly prove that the IR820 lipopeptide DDS is a safe theranostic agent for imaging-guided cancer therapy.
- Subjects
HISTIDINE; CHEMICALLY bonded nanocomposite materials; PH effect; CANCER cells; BIOCOMPATIBILITY; DOXORUBICIN; CANCER treatment; DRUG delivery devices
- Publication
Macromolecular Rapid Communications, 2014, Vol 35, Issue 9, p888
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.201300892