We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.
- Authors
Chang-Hong Wang; Cong Liu; En-Zhao Cong; Gai-Ling Xu; Ting-Ting Lv; Ying-Li Zhang; Qiu-Fen Ning; Ji-Kang Wang; Hui-Yao Nie; Yan Li
- Abstract
Background: Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population. Methods: Four polymorphisms (rs4570625, rs11178997, rs1386494 and rs7305115) of the TPH-2 gene were analyzed by using polymerase chain reaction and DNA microarray hybridization in a case-control study of 276 Han Chinese individuals (124 ODD and 152 controls). Results: In single marker analyses,there was a significant difference in the genotype (χ2 = 4.163, P = 0.041) and allele frequency (χ2 = 3.930, P = 0.047) of rs1386494 between ODD and control groups. Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups. Conclusions: These findings suggest the role of these TPH-2 gene variants in susceptibility to ODD. Some haplotypes might be the risk factors for Chinese Han children with ODD, while others might be preventable factors.
- Subjects
TRYPTOPHAN hydroxylase; OPPOSITIONAL defiant disorder in children; SINGLE nucleotide polymorphisms; GENOTYPES; HAPLOTYPES; POLYMERASE chain reaction
- Publication
Behavioral & Brain Functions, 2016, Vol 12, p1
- ISSN
1744-9081
- Publication type
Article
- DOI
10.1186/s12993-016-0113-0