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- Title
The influence of Chlorhexidine on the antibacterial effects of MTA.
- Authors
Mittag, Sven-Georg; Eißner, Christof; Zabel, Lutz; Wrbas, Karl-Thomas; Kielbassa, Andrej M.
- Abstract
Objective: To investigate the influence of Chlorhexidine in different concentrations when mixed with mineral trioxide aggregate gray (MTA-G) or white (MTA-W). The antibacterial effect on Enterococcus faecalis was used as the primary parameter. Method and Materials: Similar to the agar diffusion test, Mueller-Hinton agar plates were inoculated with E faecalis (ATCC 19433), and 14 groups (n = 21) were prepared. The specimens consisted of MTA-W and MTA-G, and these were enriched with Chlorhexidine concentrations of 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, and 2.0%. Pure MTA-W and MTA-G (each combined with distilled water) were used as controls. After incubation periods of 24 and 48 hours, the inhibiting areolae were measured. Results: Pure MTA-W, in contrast to pure MTA-G, had no bactericidal effects. With increasing Chlorhexidine concentrations of up to 1.5%, a linear increase in bactericidal activity was observed. In contrast, MTA-G showed only a low self-bactericidal influence, and the antibacterial effects with increasing Chlorhexidine concentrations were significantly lower than those of MTA-W (P< .001). Conclusion: When mixed with distilled water, pure MTA-G revealed a low bactericidal effect against E faecalis. The use of Chlorhexidine with MTA mixtures leads to an antibacterial effect against E faecalis, and within the first 48 hours, this effect is significantly higher in combination with MTA-W when compared with MTA-G.
- Subjects
ALUMINUM compounds; ANALYSIS of variance; ANTI-infective agents; COMBINATION drug therapy; CHLORHEXIDINE; DENTAL materials; ENTEROCOCCUS; HEALTH outcome assessment; OXIDES; SILICATES; T-test (Statistics); CALCIUM compounds; TREATMENT effectiveness
- Publication
Quintessence International, 2012, Vol 43, Issue 10, p901
- ISSN
0033-6572
- Publication type
Article