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- Title
Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo.
- Authors
Yali Jia; Nabil Alkayed; Ruikang K. Wang
- Abstract
Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mmbeneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mouse brain upon traumatic brain injury (TBI), with the cranium left intact, for a period of two weeks on the same animal. We show the ability of OMAG to repeatedly image 3-D cerebral vasculatures during pre- and post-traumatic phases, and to visualize the changes of regulated CBF and the vascular plasticity after TBI. The results indicate the potential of OMAG to explore the mechanism involved in the rehabilitation of TBI.
- Subjects
ANGIOGRAPHY; CEREBRAL circulation; PERFUSION; BRAIN injuries; LABORATORY mice; PHYSIOLOGICAL adaptation; BLOOD-vessel physiology; CEREBRAL cortex
- Publication
Journal of Biomedical Optics, 2009, Vol 14, Issue 4, p040505
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.3207121