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- Title
Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography.
- Authors
Junghwan Oh; Marc D. Feldman; Jihoon Kim; Pramod Sanghi; Dat Do; J. Jacob Mancuso; Nate Kemp; Mehmet Cilingiroglu; Thomas E. Milner
- Abstract
We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand white rabbits injected with monocrystalline iron oxide nanoparticles (MIONs) of <40 nm diam. MIONs taken up by macrophages was excited by an oscillating magnetic flux density and resulting nanometer tissue surface displacement was detected by DP-OCT. Frequency response of tissue surface displacement in response to an externally applied magnetic flux density was twice the stimulus frequency as expected from the equations of motion for the nanoparticle cluster.
- Subjects
NEW Zealand; ATHEROSCLEROTIC plaque; IRON oxides; OPTICAL coherence tomography; MACROPHAGES; LABORATORY rabbits
- Publication
Journal of Biomedical Optics, 2008, Vol 13, Issue 5, p54006
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.2985762