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- Title
Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors.
- Authors
Brian S. Sorg; Matthew E. Hardee; Nikita Agarwal; Benjamin J. Moeller; Mark W. Dewhirst
- Abstract
Abnormal microvasculature contributes to the pathophysiologic microenvironment of tumors. Understanding microvascular tumor oxygen transport is necessary to comprehend the factors that influence tumor biology, physiology, and therapy. Previously, we described an in vivo spectral imaging microscopy system for measurements of microvessel hemoglobin saturation (HbSat). We measure temporal fluctuations and spatial gradients in tumor microvessel oxygenation and identify instances of anastomoses between vessels with significantly different oxygenations. Slow periodic fluctuations in HbSat 20%). Shunting of inspired oxygen, presumably due to arteriovenous anastomoses, from tumor feeding arterioles to adjacent venules was imaged. This effect was confined to a region around the tumor and was not observed in nearby normal microvessels. Imaging measurements of tumor microvessel oxygen transport may offer insight to current questions regarding oxygen-related tumor biology and treatment responses, and spectral imaging may be a useful research tool in this regard.
- Subjects
PHYSIOLOGICAL transport of oxygen; HEMOGLOBIN polymorphisms; ARTERIOVENOUS anastomosis; TUMORS
- Publication
Journal of Biomedical Optics, 2008, Vol 13, Issue 1, p14026
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.2837439