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- Title
A New Tricyclic Alkaloid from Portulaca oleracea L.
- Authors
Yue, Su; Jiao, Ze-Zhao; Sun, Hong-Xiang; Jin, Tian-Yun; Xiang, Lan
- Abstract
A new tricyclic alkaloid named portulacatone ( 1), i.e., 5,6-dihydro-8,9-dihydroxy-11 H-pyrrolo[2,1- b] [3]benzazepin-11-one, together with eight known compounds, methyl 4-hydroxyphenylacetate ( 2), p-hydroxybenzaldehyde ( 3), vanillin ( 4), protocatechualdehyde ( 5), p-hydroxybenzoic acid ( 6), iseluxine ( 7), oleracein E ( 8), and (+)-( R)-feruloyl malate ( 9) were isolated from aerial parts of Portulaca oleracea L. Their structures were elucidated based on spectroscopic analyses. Among them, compounds 1- 7 and 9 were isolated from this medicinal plant for the first time. Compounds 1 and 7 showed dose-dependent scavenging activities against DPPH (2,2-diphenyl-1-picryl-hydrazyl) free radical, with EC50 values of 14.36 μ M and 9.98 μ M, respectively, more potent than the natural antioxidant vitamin C ( EC50 20.72 μ M).
- Subjects
ALKALOIDS; PORTULACA oleracea; MEDICINAL plants; BOTANICAL chemistry; CHEMICAL research
- Publication
Helvetica Chimica Acta, 2015, Vol 98, Issue 7, p961
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201400374