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- Title
Effect of Pb-exposure and B vitamin deficiencies on δ-aminolevulinic acid dehydratase activity among workers from Pb recycling plants.
- Authors
Adepu, Vinay Kumar; Kumar, H. S. Santosh; Ravibabu, Kalahasthi; Nagaraju, Raju
- Abstract
Previous studies reported that Pb exposure causes a negative association with delta-aminolevulinic acid dehydratase activity (δ-ALAD), but the impact of Pb exposure (dose and time), B vitamin deficiencies, and lifestyle factors needs to be explored. In this study, the impact of Pb exposure, B vitamin deficiencies, and lifestyle factors on δ-ALAD activity among workers exposed to Pb from the Pb-recycling process was evaluated. Blood lead levels (BLLs), B vitamins (B6, B9, and B12), hematological factors (Hb% and HCT), lifestyle factors, and δ-ALAD activity was assessed in 170 male Pb-exposed workers engaged in the Pb recycling process. BLLs are estimated using the ICP-OES method. B vitamins in serum samples from workers were determined using the ELISA method. The δ-ALAD activity in whole blood samples was determined using the spectrophotometer method. The lifestyle factors were collected using a standard questionnaire. The δ-ALAD activity was significantly decreased in workers with the habits of alcohol use, tobacco consumption, hematocrit < 41%, mild and moderate categories of anemia, vitamin B6 and B12 deficiency, and BLL categories of 10–30, 30–50, and > 50 µg/dL. Multiple regression analysis revealed that the independent variables of alcohol consumption (β = − 0.170; P = 0.025), BLLs (β = − 0.589; P = 0.001) and Hb% (β = 0.183; P = 0.001) significantly influenced the δ-ALAD activity with 44.2% (R2 = 0.442). Among the workers exposed to Pb from the Pb recycling plant, δ-ALAD activity was considerably reduced by Pb exposure, B vitamin deficiency, hematological parameters, and lifestyle factors.
- Subjects
VITAMIN B deficiency; VITAMIN B12 deficiency; LEAD exposure; MULTIPLE regression analysis; WASTE recycling; VITAMIN B complex
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2024, Vol 29, Issue 3, p375
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-023-02042-w