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- Title
Association between periodontitis and salivary 8-hydroxydeoxyguanosine among Korean rural adults.
- Authors
Shin, Myung‐Seop; Shin, Hye‐Sun; Ahn, Yoo‐Been; Kim, Hyun‐Duck
- Abstract
Objectives This study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8- OHdG) and periodontitis among community-dwelling Korean adults. Methods A total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8- OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8- OHdG. Results The high 8- OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8- OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) ( ancova, P = 0.028). Conclusions 8- OHdG was associated with periodontitis. Thus, salivary 8- OHdG could be a useful marker for periodontitis.
- Subjects
KOREA; PERIODONTITIS; SALIVA analysis; REACTIVE oxygen species; ANALYSIS of covariance; BIOMARKERS; CHI-squared test; PERIODONTIUM examination; QUESTIONNAIRES; REGRESSION analysis; RESEARCH funding; T-test (Statistics); LOGISTIC regression analysis; OXIDATIVE stress; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; DEOXYRIBONUCLEOSIDES; MANN Whitney U Test; INTRACLASS correlation
- Publication
Community Dentistry & Oral Epidemiology, 2016, Vol 44, Issue 4, p381
- ISSN
0301-5661
- Publication type
Article
- DOI
10.1111/cdoe.12225