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- Title
Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.
- Authors
Masafumi Tsujimoto; Yoshikuni Goto; Masato Maruyama; Akira Hattori
- Abstract
Abstract  It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
- Subjects
ENZYMES; AMINOPEPTIDASES; REGULATION of blood pressure; LEUCINE
- Publication
Heart Failure Reviews, 2008, Vol 13, Issue 3, p285
- ISSN
1382-4147
- Publication type
Article
- DOI
10.1007/s10741-007-9064-8