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- Title
Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.
- Authors
Ito, Seigo; Misaki, Taro; Nagasawa, Yasuyuki; Nomura, Ryota; Naka, Shuhei; Fukunaga, Akiko; Matsuoka, Daiki; Matayoshi, Saaya; Matsumoto-Nakano, Michiyo; Nakano, Kazuhiko
- Abstract
Background: The relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)—particularly with respect to galactose-deficient IgA1 (Gd-IgA1)—has not been fully elucidated. Methods: Saliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group. Results: Compared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05). Conclusion: Our findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1.
- Subjects
PORPHYROMONAS gingivalis infections; IGA glomerulonephritis; NEPHRITIS; FOCAL segmental glomerulosclerosis; CHRONIC kidney failure; POLYMERASE chain reaction
- Publication
Clinical & Experimental Nephrology, 2024, Vol 28, Issue 3, p192
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-023-02411-4