We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neoadjuvant Management of Adenocarcinoma of the Esophagus and Esophagogastric Junction: Review of Randomized Evidence and Definition of Optimum Treatment Algorithm.
- Authors
Hingorani, Mohan; Goody, Rebecca; Bozas, Georgios; Zahid, Khwaja; Mitton, David James; Jain, Prashant; Wong, Vincent; Roy, Rajarshi
- Abstract
Background: Neoadjuvant chemotherapy (nCT) or chemoradiotherapy (nCRT) are accepted standards of care for the management of adenocarcinoma of the esophagus and gastroesophageal junction. Summary: The MRC-OEO2 study established the role of 2 cycles of neoadjuvant cisplatin/fluoropyrimidine. More recently, the FLOT-AIO4 study demonstrated the superiority of perioperative FLOT chemotherapy (5FU, oxaliplatin, and docetaxel) compared to ECX (epirubicin, cisplatin, and capecitabine) regime. The results from the pivotal CROSS study established neoadjuvant CRT as a new standard of care in OG cancer. The survival benefits observed in FLOT and CROSS studies are similar [FLOT – hazard ratio 0.75 (0.62–0.92); CROSS – 0.741 (0.55–0.98)]. Key Messages: Both nCT and nCRT have been shown to be associated with survival benefit compared to surgery alone. We have performed a comprehensive review of the available evidence to define the optimum treatment algorithm and identify specific patient sub-groups who may be appropriate for the use of one or more of these neoadjuvant options.
- Subjects
THERAPEUTIC use of antimetabolites; THERAPEUTIC use of antineoplastic agents; ADENOCARCINOMA; CANCER chemotherapy; SURGICAL complications; CHEMORADIOTHERAPY; TREATMENT effectiveness; FLUOROURACIL; MEDICAL protocols; CISPLATIN; DOCETAXEL; EPIRUBICIN; COMBINED modality therapy; OXALIPLATIN; ESOPHAGEAL tumors; ALGORITHMS; OVERALL survival
- Publication
Oncology, 2023, Vol 101, Issue 9, p553
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000527716