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- Title
Usefulness of Plasma Exosomal MicroRNA-451a as a Noninvasive Biomarker for Early Prediction of Recurrence and Prognosis of Non-Small Cell Lung Cancer.
- Authors
Kanaoka, Rie; Iinuma, Hisae; Dejima, Hitoshi; Sakai, Takashi; Uehara, Hirofumi; Matsutani, Noriyuki; Kawamura, Masafumi
- Abstract
<bold><italic>Objectives:</italic></bold> The aim of this study was to clarify the usefulness of plasma exosomal microRNA-451a (miR-451a) as a novel biomarker for the early prediction of recurrence and prognosis in non-small cell lung cancer (NSCLC) patients after curative resection. <bold><italic>Methods:</italic></bold> Before surgery, plasma samples were collected and exosomal microRNA (miRNA) levels were evaluated. We first profiled specific exosomal miRNAs related to recurrence in 6 NSCLC patients with stage IA cancer by miRNA microarray. We then validated the usefulness of selected miRNAs as biomarkers using the other 285 NSCLC patients. <bold><italic>Results:</italic></bold> Plasma exosomal miR-451a showed the highest upregulation in the NSCLC patients with recurrence in the miRNA microarray analysis. A significant positive correlation was demonstrated between exosomal miR-451a levels and NSCLC tissue miR-451a levels. Exosomal miR-451a showed a significant association with lymph node metastasis, vascular invasion, and stage. In stage I, II, or III patients, the overall survival (OS) and disease-free survival (DFS) rates among the high-exosomal-miR-451a patients were significantly worse than those among the low-exosomal-miR-451a patients. In Cox multivariate analysis, exosomal miR-451a showed significance for OS and DFS. <bold><italic>Conclusion:</italic></bold> Plasma exosomal miR-451a might serve as a reliable biomarker for the prediction of recurrence and prognosis in NSCLC patients with stage I, II, or III cancer.
- Subjects
LUNG cancer prognosis; BIOMARKERS; CANCER relapse; MULTIVARIATE analysis; RNA; SURVIVAL; PROPORTIONAL hazards models; MICROARRAY technology; EXOSOMES
- Publication
Oncology, 2018, Vol 94, Issue 5, p311
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000487006