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- Title
Matrix Metalloproteinase Levels in the Differentiation of Parapneumonic Pleural Effusions.
- Authors
Oikonomidi, Smaragda; Kostikas, Konstantinos; Kalomenidis, Ioannis; Tsilioni, Irene; Daenas, Christos; Gourgoulianis, Konstantinos I.; Kiropoulos, Theodoros S.
- Abstract
Background: Matrix metalloproteinases (MMPs) have been implicated in the escalation of fibrosis and remodeling which are central to the subsequent progression of a parapneumonic pleural effusion to empyema. Objectives: The aim of this study was the assessment of MMP-2, MMP-8 and MMP-9 in parapneumonic pleural effusions in order to examine their value in the differentiation between uncomplicated and complicated parapneumonic effusions. Methods: The study included 208 consecutive patients with pleural effusions [60 parapneumonic (27 uncomplicated parapneumonic, 17 complicated parapneumonic, 16 empyemas), 24 tuberculous, 89 malignant and 35 transudates]. Concentrations of pleural fluid and serum MMP-2, MMP-8 and MMP-9 were determined by immunoassay. Results: Pleural fluid MMP-8 and MMP-9 levels were higher in complicated parapneumonic effusions or empyema than in uncomplicated effusions, while their serum levels were higher in complicated parapneumonic effusions. MMP-2 levels were higher in uncomplicated than in complicated parapneumonic effusions or empyema. Pleural fluid MMP-2/MMP-9 ratio was the best marker to differentiate complicated from uncomplicated parapneumonic effusions, with a sensitivity of 94.1% and a specificity of 77.8% at a cut-off point of 1.32 (AUC = 0.887). Conclusions: Pleural fluid MMP-2, MMP-8 and MMP-9 may provide useful information for differentiating between uncomplicated and complicated parapneumonic effusions. Copyright © 2010 S. Karger AG, Basel
- Subjects
GREECE; EMPYEMA; DIAGNOSIS of cancer in the pleura; ACADEMIC medical centers; ANALYSIS of variance; BIOMARKERS; COMPUTER software; EXUDATES &; transudates; IMMUNOASSAY; PLEURAL effusions; PNEUMONIA; PROTEOLYTIC enzymes; STATISTICS; DATA analysis; PREDICTIVE tests; RECEIVER operating characteristic curves; DIAGNOSIS; BLOOD; ANALYTICAL chemistry; CLASSIFICATION; ETIOLOGY of diseases; DISEASE complications
- Publication
Respiration, 2010, Vol 80, Issue 4, p285
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000314586