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- Title
ERAP1 Gen İfadesinin Plazma Hücre Diskrazilerinde İncelenmesi.
- Authors
Sarıman, Melda; Karaçam, Büşra; Ayer, Mesut; Ekmekci, Sema Sırma; Suer, İlknur; Çefle, Kıvanç; Palanduz, Şükrü; Öztürk, Şükrü; Nalçacı, Meliha; Abacı, Neslihan
- Abstract
Objective: Monoclonal gammopathy of unknown significance (MGUS) is asymptomatic, and multiple myeloma (MM) is a symptomatic plasma cell dyscrasia. In our RNA sequencing study, the expression of the ERAP1 gene from the cell pools of MM patients and healthy bone marrow controls was found to be high in the patient group and it was investigated in this study whether it has a direct or indirect effect on MM pathogenesis. Method: The expression levels of the ERAP1 gene from the bone marrow materials of 38 newly diagnosed and untreated MM patients, 23 MGUS, and 16 control groups were examined by the qRT-PCR method. The results were analyzed in the SPSS.25 statistics program. Results: Expression levels of the ERAP1 gene were not statistically significant between the MM group, the MGUS group, and the control group (p>0.05) (p=0.280). Conclusion: The ERAP1 candidate gene with high RPKM value in our RNA sequencing study did not find a significant relationship between the validated patient and control groups. This issue should be investigated in more samples to reach a definite conclusion. In addition, it was concluded that the polymorphisms of the ERAP1 gene, highly polymorphic, should be studied in this aspect, and its effect on gene expression in myeloma.
- Publication
Medical Journal of Istanbul Kanuni Sultan Süleyman / İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 2022, Vol 14, Issue 2, p120
- ISSN
2148-273X
- Publication type
Article
- DOI
10.14744/iksstd.2021.29494