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- Title
EFFECTS OF URINARY ACIDITY ON THE DEVELOPMENT OF NEFHROCALCINOSIS IN RATS.
- Authors
Goulding, Ailsa; Malthus, R. S.
- Abstract
The article discusses effects of urinary acidity on the development of nephrocalcinosis in rats. Supplements of ammonium chloride were used to acidify the urine the supplements of sodium bicarbonate to make it alkaline. In first experiment 24 male and 26 female rats were allocated to 5 groups and fed either the basal diet or diets containing ammonium chloride or sodium bicarbonate supplements. A daily measurement of urinary pH was made from each rat. Ingestion of ammonium chloride is equivalent to ingestion of hydrochloric acid because the ammonium ion is converted to ammonia and thence to urea in the liver, leaving hydrogen and chloride ions to be excreted.
- Subjects
LABORATORY rats; KIDNEY calcification; URINALYSIS; AMMONIUM compounds; SODIUM bicarbonate; HYDROGEN-ion concentration
- Publication
Australian Journal of Experimental Biology & Medical Science, 1970, Vol 48, Issue 3, p301
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1970.32