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- Title
Adverse maternal and fetal outcomes in pregnant women recovering from asymptomatic COVID-19 and fetal Doppler ultrasound parameters.
- Authors
Kaplan, Ela; Erten, Mehmet; Ekinci, Tekin; Kaplan, Selçuk
- Abstract
Introduction: Coronavirus 2019 (COVID-19) is a newly emerging viral disease with multisystemic involvement. The aim of this study is to determine the changes in Doppler ultrasound (DUS) parameters, adverse maternal and fetal outcomes and maternal biochemical changes in the 3rd trimester in pregnant women who experienced COVID-19 asymptomatically in the 1st and 2nd trimesters. Material and methods: This study is a tertiary center retrospective case-control study in which 223 pregnant women recovering from asymptomatic COVID-19 and 223 pregnant women who did not have COVID-19 were included. Medial cerebral artery (MCA) and umbilical artery (UA) vascular resistance parameters and cerebroplacental ratio (CPR) were determined by DUS for both groups. Adverse maternal outcomes (gestational diabetes mellitus [GDM], intrahepatic cholestasis of pregnancy [ICP], preeclampsia) and adverse fetal outcomes (preterm delivery, stillbirth, oligohydramnios, intrauterine growth restriction [IUGR], macrosomia and placental abnormalities) were noted in both groups. Statistical analyses were performed and p < 0.05 was considered significant. Results: UA-pulsatility index (PI) (p < 0.001), UA-resistivity index (RI) (p = 0.047), UA-systolic/diastolic (S/D) (p = 0.002), MCA-PI (p = 0.038), MCA-RI (p = 0.027) and MCA-S/D (p < 0.001) values increased in the group of pregnant women recovered from asymptomatic COVID-19. When biochemical values were assessed, total bilirubin value (p = 0.022) and glucose value (p < 0.001) were significantly higher in the group of pregnant women recovered from asymptomatic COVID-19. Gestational diabetes mellitus (p = 0.025), ICP (p = 0.023), preeclampsia (p = 0.036), preterm delivery (p = 0.02), IUGR (p < 0.001), and oligohydramnios (p = 0.002) rates were higher in pregnant women recovered from asymptomatic COVID-19. Conclusions: Even if COVID-19 has an asymptomatic course in pregnant women, it can cause maternal and fetal adverse outcomes. Changes in uteroplacental vascular structures after COVID-19 infection can be examined by Doppler ultrasonography to help prevent undesirable fetal and maternal complications.
- Subjects
FETAL anatomy; ULTRASONIC imaging equipment; CEREBRAL artery physiology; BLOOD sugar analysis; DOPPLER ultrasonography; MOTHERS; THIRD trimester of pregnancy; GESTATIONAL diabetes; PREMATURE infants; FETAL growth retardation; RHEOLOGY; STATISTICAL sampling; FISHER exact test; LOGISTIC regression analysis; BIOCHEMISTRY; PREGNANCY outcomes; PSYCHOLOGY of women; TERTIARY care; RETROSPECTIVE studies; BILIRUBIN; CHI-squared test; DESCRIPTIVE statistics; VASCULAR resistance; CASE-control method; CONVALESCENCE; PREECLAMPSIA; AMNION; DIASTOLIC blood pressure; UMBILICAL arteries; AMNIOTIC liquid; PREGNANCY complications; CLINICS; SYSTOLIC blood pressure; DATA analysis software; COVID-19; CHOLESTASIS; PREGNANCY
- Publication
Journal of Health Inequalities, 2023, Vol 9, Issue 2, p161
- ISSN
2450-5927
- Publication type
Article
- DOI
10.5114/jhi.2023.131229