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- Title
Plasma Level of Matrix Metalloproteinase 9 In Beta Thalassemia.
- Authors
Elbiheery Youssif, Samah Abdelrasheed; Badr, Mohamed Ahmed; Hassan, Tamer Hasan; Abd El Fattah, Nermin Raafat
- Abstract
Background: Beta-thalassemia major (β-TM) is a genetic hemoglobinopathy that necessitates frequent blood transfusions and is brought on by defective β-globin chain synthesis. The matrix metalloproteinases (MMPs) family of zinc-dependent endopeptidases is in responsible of both physiological and pathological tissue restructuring. This study aims at assessing plasma levels of matrix metalloproteinase 9 in patients with beta thalassemia. Methods: This case-control study was done in the pediatric hematology out-patient clinic of Zagazig University Hospitals from March 2019 till October 2019. We included 50 patients more than 10 years of both sexes and with beta thalassemia during their regular follow up visits. 50 age- and sex-matched healthy children were also included as a control group. All participants were subjected to full medical history and precise clinical examination. Routine laboratory investigations for beta thalassemia were done. Biochemical study of plasma matrix metalloproteinase 9 was also conducted by ELISA. Results: MMP-9 was significantly higher in patients than controls (112.5 versus 18.5 pg/ml), respectively. Regarding the relation between serum level of MMP-9 and demographic characteristics of patients, though patients >15 years and females had higher levels of MMP-9 yet, the difference didn't reach a statistically significant level. MMP-9 levels were significantly higher in patients with complications than those without complications. Conclusion: Thalassemia major patients had considerably increased plasma MMP-9 levels. MMP-9 seems to be a valuable marker in those patients.
- Subjects
BETA-Thalassemia; MATRIX metalloproteinases; ENDOPEPTIDASES; PEDIATRIC hematology; DEMOGRAPHIC characteristics
- Publication
Zagazig University Medical Journal, 2024, Vol 30, p328
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/ZUMJ.2022.161721.2639