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- Title
Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting.
- Authors
Brioschi, Maura; Gianazza, Erica; Andreini, Daniele; Mushtaq, Saima; Cavallotti, Laura; Veglia, Fabrizio; Tedesco, Calogero C.; Colombo, Gualtiero I.; Pepi, Mauro; Polvani, Gianluca; Tremoli, Elena; Parolari, Alessandro; Banfi, Cristina
- Abstract
Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants. In a nested case–control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG. We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.
- Subjects
CORONARY artery bypass; CORONARY arteries; INTERNAL thoracic artery; SEALING devices; CORONARY artery disease; SERUM albumin
- Publication
Antioxidants, 2022, Vol 11, Issue 4, pN.PAG
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11040702